CHOLESTEROL - Hero or Villain?
TOC
Page 1
Meet Cholesterol...
...Its Backbone
... And Its Crime
Page 2
Lesson Objectives
Concept Map
Page 3
1. Cholesterol is a crucial component of cell membranes
2. Cholesterol is the precursor of bile salts
3. Cholesterol is the precursor of steroid hormones
4. Cholesterol is the precursor of vitamin D
5. Excessive levels of cholesterol in blood lead to cardiovascular disease
Page 4
The Substrate
The Site of Synthesis
Page 5
Stage 1: Mevalonate Synthesis
Stage 2: Conversion of Mevalonate to Activated Isoprenes
Stage 3: Condensation of Isoprenoids to Form Squalene
Stage 4: Conversion of Squalene to Lanosterol and Cholesterol
Page 6
A. Gene transcription and new protein synthesis
B. Protein (enzyme) degradation by proteolysis
C. Phosphorylation
D. Competitve inhibition
Page 7
Bile Acids
Bile Salts
Page 8
Page 9
1. Chylomicrons
2. Very low density lipoproteins (VLDL)
3. Intermediate density lipoproteins (IDL)
4. Low density lipoproteins (LDL)
5. High density lipoproteins (HDL)
Page 10
Page 11
Page 12
Heart Attack
Page 13
Page 14
Page:
1
|
2
|
3
|
4
|
5
|
6
|
7
|
8
|
9
|
10
|
11
| 12
|
13
|
14
Heart Attack
toc
|
return to top
|
previous page
|
next page
