Contents

Meet Cholesterol: Meet Cholesterol...; ...Its Backbone; ... And Its Crime

What Shoud You Know About Cholesterol?: Lesson Objectives; Concept Map

Why Is It Important to Become Familiar with Cholesterol?: 1. Cholesterol is a crucial component of cell membranes; 2. Cholesterol is the precursor of bile salts; 3. Cholesterol is the precursor of steroid hormones; 4. Cholesterol is the precursor of vitamin D; 5. Excessive levels of cholesterol in blood lead to cardiovascular disease

Where is Cholesterol Made in the Cell?: The Substrate; The Site of Synthesis

How Is Cholesterol Made in Your Body?: Stage 1: Mevalonate Synthesis; Stage 2: Conversion of Mevalonate to Activated Isoprenes; Stage 3: Condensation of Isoprenoids to Form Squalene; Stage 4: Conversion of Squalene to Lanosterol and Cholesterol

How is the Synthesis of Cholesterol Regulated?: A. Gene transcription and new protein synthesis; B. Protein (enzyme) degradation by proteolysis; C. Phosphorylation; D. Competitve inhibition

How Does Cholesterol Aid in Digestion?: Bile Acids; Bile Salts

Does Cholesterol Act Alone?

How are Lipoproteins Classifed?: 1. Chylomicrons; 2. Very low density lipoproteins (VLDL); 3. Intermediate density lipoproteins (IDL); 4. Low density lipoproteins (LDL); 5. High density lipoproteins (HDL)

Lipoproteins and Your Health

Atherosclerosis

Heart Disease: Heart Attack

Cholesterol Mania

The Verdict